2-Pyridineethanol, β,β-difluoro-5-methyl- - Names and Identifiers
2-Pyridineethanol, β,β-difluoro-5-methyl- - Physico-chemical Properties
| Molecular Formula | C8H9F2NO
|
| Molar Mass | 173.16 |
2-Pyridineethanol, β,β-difluoro-5-methyl- - Introduction
2,2-difluoro-2-(5-methylpyridin-2-yl)ethanol is an organic compound with the chemical formula C9H10F2NO. The following is a description of the properties, uses, preparation and safety information of this compound:
Nature:
-Appearance: It is a colorless to light yellow oily liquid.
-Solubility: It is soluble in ethanol, chloroform and dichloromethane, slightly soluble in water.
Use:
-2,2-difluoro-2-(5-methylpyridin-2-yl)ethanol is commonly used as an intermediate in organic synthesis. It can be used to synthesize drugs, pesticides and other organic compounds.
-In organic synthesis, it is often used as a reducing agent, reducing coupling agent and crosslinking reagent.
Method:
-2,2-difluoro-2-(5-methylpyridin-2-yl)ethanol can be prepared by the following steps:
1.5-methyl pyridine and trimethyl pyrophosphate are heated to react under nitrogen protection to obtain 5-methyl pyridin-2-one.
2.5-methyl pyridin -2-one is reacted with difluoromethyl sulfuryl fluoride to generate 5-methyl pyridin -2-yl methyl sulfuryl fluoride.
3. 5-methylpyridin-2-ylmethylsulfuryl fluoride reacts with 2-fluoroethanol to generate 2,2-difluoro-2-(5-methylpyridin-2-yl)ethanol.
Safety Information:
-2,2-difluoro-2-(5-methylpyridin-2-yl)ethanol should be used in a well-ventilated area, avoiding inhalation and contact with skin, eyes or clothing.
-When using, please wear appropriate personal protective equipment, such as chemical safety glasses, protective gloves and protective clothing.
-If inhaled or exposed to the compound, seek medical advice immediately.
Last Update：2024-04-09 02:00:51